Aquaporina 1

Aquaporina 1 (Colton blood group)
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1FQY, 1H6I, 1IH5
Identificadores
Símbolos	AQP1; AQP-CHIP; CHIP28; CO
IDs externos	OMIM: 107776 MGI: 103201 HomoloGene: 68051 IUPHAR: AQP1 GeneCards: AQP1 Gene
Ontologia do gene
Função molecular	•intracellular cGMP activated cation channel activity; •potassium channel activity; •water transmembrane transporter activity; •protein binding; •ammonium transmembrane transporter activity; •potassium ion transmembrane transporter activity; •glycerol transmembrane transporter activity; •water channel activity; •transmembrane transporter activity; •nitric oxide transmembrane transporter activity; •carbon dioxide transmembrane transporter activity;
Componente celular	•nucleus; •cytoplasm; •plasma membrane; •integral component of plasma membrane; •brush border; •basal plasma membrane; •basolateral plasma membrane; •apical plasma membrane; •symbiont-containing vacuole; •symbiont-containing vacuole membrane; •brush border membrane; •nuclear membrane; •sarcolemma; •apical part of cell; •extracellular vesicular exosome;
Processo biológico	•renal water transport; •cGMP biosynthetic process; •potassium ion transport; •water transport; •cell volume homeostasis; •carbon dioxide transport; •ammonium transport; •bicarbonate transport; •glycerol transport; •cellular homeostasis; •lateral ventricle development; •pancreatic juice secretion; •nitric oxide transport; •establishment or maintenance of actin cytoskeleton polarity; •cerebrospinal fluid secretion; •cellular response to stress; •cellular response to UV; •transepithelial water transport; •carbon dioxide transmembrane transport; •odontogenesis; •response to drug; •negative regulation of apoptotic process; •negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; •small molecule metabolic process; •positive regulation of angiogenesis; •positive regulation of saliva secretion; •positive regulation of fibroblast proliferation; •multicellular organismal water homeostasis; •transmembrane transport; •cellular response to hydrogen peroxide; •cellular response to inorganic substance; •cellular response to mechanical stimulus; •cellular response to copper ion; •cellular response to mercury ion; •cellular response to retinoic acid; •cellular response to cAMP; •cellular response to hypoxia; •cellular response to salt stress; •cellular hyperosmotic response; •cellular response to dexamethasone stimulus; •cellular response to nitric oxide; •potassium ion transmembrane transport; •ammonium transmembrane transport; •maintenance of symbiont-containing vacuole by host;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

A aquaporina 1 (AQP1) é um canal de água amplamente expresso em células, e cujas funções fisiológicas nos rins têm sido muito estudadas.

É encontrada na membrana basolateral e na membrana apical dos túbulos próximais, na porção descendente da alça de Henle e na porção descendente dos capilares peritubulares (vasa recta).

É adicionalmente encontrada em eritrócitos, no endotélio vascular, no tracto gastrointestinal, glândulas sudoríparas e nos pulmões.

Esta proteína não sofre regulação pela vasopressina